The link between formal thought disorder and social functioning in schizophrenia: A meta-analysis

BACKGROUND. Formal thought disorder (FTD) and social functioning impairments are core symptoms of schizophrenia. Although both have been observed for over a century, the strength of the relationship between FTD and social functioning remains unclear. Furthermore, a variety of methodological approach...

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Autores principales: Marggraf, Matthew P., Lysaker, Paul H., Salyers, Michelle P., Minor, Kyle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355127/
https://www.ncbi.nlm.nih.gov/pubmed/32200776
http://dx.doi.org/10.1192/j.eurpsy.2020.30
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author Marggraf, Matthew P.
Lysaker, Paul H.
Salyers, Michelle P.
Minor, Kyle S.
author_facet Marggraf, Matthew P.
Lysaker, Paul H.
Salyers, Michelle P.
Minor, Kyle S.
author_sort Marggraf, Matthew P.
collection PubMed
description BACKGROUND. Formal thought disorder (FTD) and social functioning impairments are core symptoms of schizophrenia. Although both have been observed for over a century, the strength of the relationship between FTD and social functioning remains unclear. Furthermore, a variety of methodological approaches have been used to assess these constructs—which may contribute to inconsistency in reported associations. This meta-analysis aimed to: (a) systematically test the relationship between FTD and social functioning and (b) determine if the methodology used to assess FTD and/or social functioning moderates this relationship. METHODS. Following Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) guidelines, a targeted literature search was conducted on studies examining the relationship between FTD and social functioning. Correlations were extracted and used to calculate weighted mean effect sizes using a random effects model. RESULTS. A total of 1,478 participants across 13 unique studies were included in this meta-analysis. A small-medium inverse association (r = −0.23, p < 0.001) was observed between FTD and social functioning. Although heterogeneity analyses produced a significant Q-statistic (Q = 52.77, p = <0.001), the relationship between FTD and social functioning was not moderated by methodology, study quality, demographic variables, or clinical factors. CONCLUSIONS. Findings illustrate a negative association between FTD and social functioning. Despite differences in the methodological approach used and type of information assessed, measurement type and clinical factors did not moderate the relationship between FTD and social functioning. Future studies should explore whether other variables, such as cognitive processes (e.g., social cognition), may account for variability in associations between these constructs.
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spelling pubmed-73551272020-07-17 The link between formal thought disorder and social functioning in schizophrenia: A meta-analysis Marggraf, Matthew P. Lysaker, Paul H. Salyers, Michelle P. Minor, Kyle S. Eur Psychiatry Review/Meta-analyses BACKGROUND. Formal thought disorder (FTD) and social functioning impairments are core symptoms of schizophrenia. Although both have been observed for over a century, the strength of the relationship between FTD and social functioning remains unclear. Furthermore, a variety of methodological approaches have been used to assess these constructs—which may contribute to inconsistency in reported associations. This meta-analysis aimed to: (a) systematically test the relationship between FTD and social functioning and (b) determine if the methodology used to assess FTD and/or social functioning moderates this relationship. METHODS. Following Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) guidelines, a targeted literature search was conducted on studies examining the relationship between FTD and social functioning. Correlations were extracted and used to calculate weighted mean effect sizes using a random effects model. RESULTS. A total of 1,478 participants across 13 unique studies were included in this meta-analysis. A small-medium inverse association (r = −0.23, p < 0.001) was observed between FTD and social functioning. Although heterogeneity analyses produced a significant Q-statistic (Q = 52.77, p = <0.001), the relationship between FTD and social functioning was not moderated by methodology, study quality, demographic variables, or clinical factors. CONCLUSIONS. Findings illustrate a negative association between FTD and social functioning. Despite differences in the methodological approach used and type of information assessed, measurement type and clinical factors did not moderate the relationship between FTD and social functioning. Future studies should explore whether other variables, such as cognitive processes (e.g., social cognition), may account for variability in associations between these constructs. Cambridge University Press 2020-03-23 /pmc/articles/PMC7355127/ /pubmed/32200776 http://dx.doi.org/10.1192/j.eurpsy.2020.30 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review/Meta-analyses
Marggraf, Matthew P.
Lysaker, Paul H.
Salyers, Michelle P.
Minor, Kyle S.
The link between formal thought disorder and social functioning in schizophrenia: A meta-analysis
title The link between formal thought disorder and social functioning in schizophrenia: A meta-analysis
title_full The link between formal thought disorder and social functioning in schizophrenia: A meta-analysis
title_fullStr The link between formal thought disorder and social functioning in schizophrenia: A meta-analysis
title_full_unstemmed The link between formal thought disorder and social functioning in schizophrenia: A meta-analysis
title_short The link between formal thought disorder and social functioning in schizophrenia: A meta-analysis
title_sort link between formal thought disorder and social functioning in schizophrenia: a meta-analysis
topic Review/Meta-analyses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355127/
https://www.ncbi.nlm.nih.gov/pubmed/32200776
http://dx.doi.org/10.1192/j.eurpsy.2020.30
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