Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

Fifteen new quinazolinone derivatives bearing benzenesulfonamide moiety with variable acetamide tail were synthesized. The structures assigned to the products were concordant with the microanalytical and spectral data. Compounds 4–18 were screened for their ability to induce the antioxidant enzyme N...

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Detalles Bibliográficos
Autores principales: Soliman, Aiten M., Karam, Heba M., Mekkawy, Mai H., Higgins, Maureen, Dinkova-Kostova, Albena T., Ghorab, Mostafa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355233/
https://www.ncbi.nlm.nih.gov/pubmed/32502866
http://dx.doi.org/10.1016/j.ejmech.2020.112467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355233/
https://www.ncbi.nlm.nih.gov/pubmed/32502866
http://dx.doi.org/10.1016/j.ejmech.2020.112467

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