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Mutational signature learning with supervised negative binomial non-negative matrix factorization

MOTIVATION: Understanding the underlying mutational processes of cancer patients has been a long-standing goal in the community and promises to provide new insights that could improve cancer diagnoses and treatments. Mutational signatures are summaries of the mutational processes, and improving the...

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Detalles Bibliográficos
Autores principales: Lyu, Xinrui, Garret, Jean, Rätsch, Gunnar, Lehmann, Kjong-Van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355241/
https://www.ncbi.nlm.nih.gov/pubmed/32657388
http://dx.doi.org/10.1093/bioinformatics/btaa473