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CRISPRL and: Interpretable large-scale inference of DNA repair landscape based on a spectral approach
SUMMARY: We propose a new spectral framework for reliable training, scalable inference and interpretable explanation of the DNA repair outcome following a Cas9 cutting. Our framework, dubbed CRISPRL and, relies on an unexploited observation about the nature of the repair process: the landscape of th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355252/ https://www.ncbi.nlm.nih.gov/pubmed/32657417 http://dx.doi.org/10.1093/bioinformatics/btaa505 |