Combining phenome-driven drug-target interaction prediction with patients’ electronic health records-based clinical corroboration toward drug discovery

MOTIVATION: Predicting drug–target interactions (DTIs) using human phenotypic data have the potential in eliminating the translational gap between animal experiments and clinical outcomes in humans. One challenge in human phenome-driven DTI predictions is integrating and modeling diverse drug and di...

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Detalles Bibliográficos
Autores principales: Zhou, Mengshi, Zheng, Chunlei, Xu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Studies of Phenotypes and Clinical Applications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355254/
https://www.ncbi.nlm.nih.gov/pubmed/32657406
http://dx.doi.org/10.1093/bioinformatics/btaa451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355254/
https://www.ncbi.nlm.nih.gov/pubmed/32657406
http://dx.doi.org/10.1093/bioinformatics/btaa451

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