Geometric potentials from deep learning improve prediction of CDR H3 loop structures

MOTIVATION: Antibody structure is largely conserved, except for a complementarity-determining region featuring six variable loops. Five of these loops adopt canonical folds which can typically be predicted with existing methods, while the remaining loop (CDR H3) remains a challenge due to its highly...

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Detalles Bibliográficos
Autores principales: Ruffolo, Jeffrey A, Guerra, Carlos, Mahajan, Sai Pooja, Sulam, Jeremias, Gray, Jeffrey J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Macromolecular Sequence, Structure, and Function
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355305/
https://www.ncbi.nlm.nih.gov/pubmed/32657412
http://dx.doi.org/10.1093/bioinformatics/btaa457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355305/
https://www.ncbi.nlm.nih.gov/pubmed/32657412
http://dx.doi.org/10.1093/bioinformatics/btaa457

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