Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle

mRNA is a novel class of therapeutic modality that holds great promise in vaccination, protein replacement therapy, cancer immunotherapy, immune cell engineering etc. However, optimization of mRNA molecules and efficient in vivo delivery are quite important but challenging for its broad application....

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Detalles Bibliográficos
Autores principales: Yang, Tongren, Li, Chunhui, Wang, Xiaoxia, Zhao, Deyao, Zhang, Mengjie, Cao, Huiqing, Liang, Zicai, Xiao, Haihua, Liang, Xing-Jie, Weng, Yuhua, Huang, Yuanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355334/
https://www.ncbi.nlm.nih.gov/pubmed/32691013
http://dx.doi.org/10.1016/j.bioactmat.2020.07.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355334/
https://www.ncbi.nlm.nih.gov/pubmed/32691013
http://dx.doi.org/10.1016/j.bioactmat.2020.07.003

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