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Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle
mRNA is a novel class of therapeutic modality that holds great promise in vaccination, protein replacement therapy, cancer immunotherapy, immune cell engineering etc. However, optimization of mRNA molecules and efficient in vivo delivery are quite important but challenging for its broad application....
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
KeAi Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355334/ https://www.ncbi.nlm.nih.gov/pubmed/32691013 http://dx.doi.org/10.1016/j.bioactmat.2020.07.003 |