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Saturation Mutagenesis for Phenylalanine Ammonia Lyases of Enhanced Catalytic Properties

Phenylalanine ammonia-lyases (PALs) are attractive biocatalysts for the stereoselective synthesis of non-natural phenylalanines. The rational design of PALs with extended substrate scope, highlighted the substrate specificity-modulator role of residue I460 of Petroselinum crispum PAL. Herein, satura...

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Detalles Bibliográficos
Autores principales: Tomoiagă, Raluca Bianca, Tork, Souad Diana, Horváth, Ilka, Filip, Alina, Nagy, Levente Csaba, Bencze, László Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355458/
https://www.ncbi.nlm.nih.gov/pubmed/32486192
http://dx.doi.org/10.3390/biom10060838