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Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling
In this study, the putative correlation between the molecular mobility of a polymer and the ball milling drug amorphization kinetics (i.e., time to reach full drug amorphization, t(a)) was studied using different grades of dextran (Dex) and polyvinylpyrrolidone (PVP) and the two model drugs indometh...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355600/ https://www.ncbi.nlm.nih.gov/pubmed/32471023 http://dx.doi.org/10.3390/pharmaceutics12060483 |
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author | Asgreen, Camilla Knopp, Matthias Manne Skytte, Jeppe Löbmann, Korbinian |
author_facet | Asgreen, Camilla Knopp, Matthias Manne Skytte, Jeppe Löbmann, Korbinian |
author_sort | Asgreen, Camilla |
collection | PubMed |
description | In this study, the putative correlation between the molecular mobility of a polymer and the ball milling drug amorphization kinetics (i.e., time to reach full drug amorphization, t(a)) was studied using different grades of dextran (Dex) and polyvinylpyrrolidone (PVP) and the two model drugs indomethacin (IND) and chloramphenicol (CAP). In general, IND had lower t(a) values than CAP, indicating that IND amorphized faster than CAP in the presence of the polymers. In addition, an increase in polymer molecular weight (M(w)) also led to an increase in t(a) for all systems investigated up to a critical M(w) for each polymer, which was in line with an increase of the glass transition temperature (T(g)) up to the critical M(w) of each polymer. Hence, the increase in t(a) seemed to correlate well with the T(g)/M(w) of the polymers, which indicates that the polymers’ molecular mobility had an influence on the drug amorphization kinetics during ball milling. |
format | Online Article Text |
id | pubmed-7355600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73556002020-07-23 Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling Asgreen, Camilla Knopp, Matthias Manne Skytte, Jeppe Löbmann, Korbinian Pharmaceutics Communication In this study, the putative correlation between the molecular mobility of a polymer and the ball milling drug amorphization kinetics (i.e., time to reach full drug amorphization, t(a)) was studied using different grades of dextran (Dex) and polyvinylpyrrolidone (PVP) and the two model drugs indomethacin (IND) and chloramphenicol (CAP). In general, IND had lower t(a) values than CAP, indicating that IND amorphized faster than CAP in the presence of the polymers. In addition, an increase in polymer molecular weight (M(w)) also led to an increase in t(a) for all systems investigated up to a critical M(w) for each polymer, which was in line with an increase of the glass transition temperature (T(g)) up to the critical M(w) of each polymer. Hence, the increase in t(a) seemed to correlate well with the T(g)/M(w) of the polymers, which indicates that the polymers’ molecular mobility had an influence on the drug amorphization kinetics during ball milling. MDPI 2020-05-27 /pmc/articles/PMC7355600/ /pubmed/32471023 http://dx.doi.org/10.3390/pharmaceutics12060483 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Asgreen, Camilla Knopp, Matthias Manne Skytte, Jeppe Löbmann, Korbinian Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling |
title | Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling |
title_full | Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling |
title_fullStr | Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling |
title_full_unstemmed | Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling |
title_short | Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling |
title_sort | influence of the polymer glass transition temperature and molecular weight on drug amorphization kinetics using ball milling |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355600/ https://www.ncbi.nlm.nih.gov/pubmed/32471023 http://dx.doi.org/10.3390/pharmaceutics12060483 |
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