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Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling

In this study, the putative correlation between the molecular mobility of a polymer and the ball milling drug amorphization kinetics (i.e., time to reach full drug amorphization, t(a)) was studied using different grades of dextran (Dex) and polyvinylpyrrolidone (PVP) and the two model drugs indometh...

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Autores principales: Asgreen, Camilla, Knopp, Matthias Manne, Skytte, Jeppe, Löbmann, Korbinian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355600/
https://www.ncbi.nlm.nih.gov/pubmed/32471023
http://dx.doi.org/10.3390/pharmaceutics12060483
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author Asgreen, Camilla
Knopp, Matthias Manne
Skytte, Jeppe
Löbmann, Korbinian
author_facet Asgreen, Camilla
Knopp, Matthias Manne
Skytte, Jeppe
Löbmann, Korbinian
author_sort Asgreen, Camilla
collection PubMed
description In this study, the putative correlation between the molecular mobility of a polymer and the ball milling drug amorphization kinetics (i.e., time to reach full drug amorphization, t(a)) was studied using different grades of dextran (Dex) and polyvinylpyrrolidone (PVP) and the two model drugs indomethacin (IND) and chloramphenicol (CAP). In general, IND had lower t(a) values than CAP, indicating that IND amorphized faster than CAP in the presence of the polymers. In addition, an increase in polymer molecular weight (M(w)) also led to an increase in t(a) for all systems investigated up to a critical M(w) for each polymer, which was in line with an increase of the glass transition temperature (T(g)) up to the critical M(w) of each polymer. Hence, the increase in t(a) seemed to correlate well with the T(g)/M(w) of the polymers, which indicates that the polymers’ molecular mobility had an influence on the drug amorphization kinetics during ball milling.
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spelling pubmed-73556002020-07-23 Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling Asgreen, Camilla Knopp, Matthias Manne Skytte, Jeppe Löbmann, Korbinian Pharmaceutics Communication In this study, the putative correlation between the molecular mobility of a polymer and the ball milling drug amorphization kinetics (i.e., time to reach full drug amorphization, t(a)) was studied using different grades of dextran (Dex) and polyvinylpyrrolidone (PVP) and the two model drugs indomethacin (IND) and chloramphenicol (CAP). In general, IND had lower t(a) values than CAP, indicating that IND amorphized faster than CAP in the presence of the polymers. In addition, an increase in polymer molecular weight (M(w)) also led to an increase in t(a) for all systems investigated up to a critical M(w) for each polymer, which was in line with an increase of the glass transition temperature (T(g)) up to the critical M(w) of each polymer. Hence, the increase in t(a) seemed to correlate well with the T(g)/M(w) of the polymers, which indicates that the polymers’ molecular mobility had an influence on the drug amorphization kinetics during ball milling. MDPI 2020-05-27 /pmc/articles/PMC7355600/ /pubmed/32471023 http://dx.doi.org/10.3390/pharmaceutics12060483 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Asgreen, Camilla
Knopp, Matthias Manne
Skytte, Jeppe
Löbmann, Korbinian
Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling
title Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling
title_full Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling
title_fullStr Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling
title_full_unstemmed Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling
title_short Influence of the Polymer Glass Transition Temperature and Molecular Weight on Drug Amorphization Kinetics Using Ball Milling
title_sort influence of the polymer glass transition temperature and molecular weight on drug amorphization kinetics using ball milling
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355600/
https://www.ncbi.nlm.nih.gov/pubmed/32471023
http://dx.doi.org/10.3390/pharmaceutics12060483
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