Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholinesterase by oximes. While currently available oximes a...

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Detalles Bibliográficos
Autores principales: Calas, André-Guilhem, Hanak, Anne-Sophie, Jaffré, Nina, Nervo, Aurélie, Dias, José, Rousseau, Catherine, Courageux, Charlotte, Brazzolotto, Xavier, Villa, Pascal, Obrecht, Adeline, Goossens, Jean-François, Landry, Christophe, Hachani, Johan, Gosselet, Fabien, Dehouck, Marie-Pierre, Yerri, Jagadeesh, Kliachyna, Maria, Baati, Rachid, Nachon, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355633/
https://www.ncbi.nlm.nih.gov/pubmed/32512884
http://dx.doi.org/10.3390/biom10060858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355633/
https://www.ncbi.nlm.nih.gov/pubmed/32512884
http://dx.doi.org/10.3390/biom10060858

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