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A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression

A new co-processed, rice starch-based excipient (CS) was developed via a spray-drying technique. Native rice starch (RS) was suspended in aqueous solutions of 10%–15% cross-linked carboxymethyl rice starch (CCMS) and 0.5%–6.75% silicon dioxide (in the form of sodium silicate), before spray drying. T...

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Autores principales: Trisopon, Karnkamol, Kittipongpatana, Nisit, Kittipongpatana, Ornanong Suwannapakul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355677/
https://www.ncbi.nlm.nih.gov/pubmed/32517241
http://dx.doi.org/10.3390/pharmaceutics12060518
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author Trisopon, Karnkamol
Kittipongpatana, Nisit
Kittipongpatana, Ornanong Suwannapakul
author_facet Trisopon, Karnkamol
Kittipongpatana, Nisit
Kittipongpatana, Ornanong Suwannapakul
author_sort Trisopon, Karnkamol
collection PubMed
description A new co-processed, rice starch-based excipient (CS) was developed via a spray-drying technique. Native rice starch (RS) was suspended in aqueous solutions of 10%–15% cross-linked carboxymethyl rice starch (CCMS) and 0.5%–6.75% silicon dioxide (in the form of sodium silicate), before spray drying. The resulting CSs were obtained as spherical agglomerates, with improved flowability. The compressibility study revealed an improved plastic deformation profile of RS, leading to better compaction and tensile strength. The presence of CCMS also ensured a rapid disintegration of the compressed tablets. CS-CCMS:SiO(2) (10:2.7), prepared with 10% CCMS, 2.7% silicon dioxide, and 40% solid content, was found to exhibit the best characteristics. Compared to the two commercial DC excipients, Prosolv(®) and Tablettose(®), the flow property of CS-CCMS:SiO(2) (10:2.7) was not significantly different, while the tensile strength was 23%: lower than that of Prosolv(®) but 4 times higher than that of Tablettose(®) at 196 MPa compression force. The disintegration time of CS-CCMS:SiO(2) (10:2.7) tablet (28 s) was practically identical to that of Tablettose(®) tablet (26 s) and far superior to that of Prosolv(®) tablet (>30 min). These results show that CSs could potentially be employed as a multifunctional excipient for the manufacturing of commercial tablets by DC.
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spelling pubmed-73556772020-07-23 A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression Trisopon, Karnkamol Kittipongpatana, Nisit Kittipongpatana, Ornanong Suwannapakul Pharmaceutics Article A new co-processed, rice starch-based excipient (CS) was developed via a spray-drying technique. Native rice starch (RS) was suspended in aqueous solutions of 10%–15% cross-linked carboxymethyl rice starch (CCMS) and 0.5%–6.75% silicon dioxide (in the form of sodium silicate), before spray drying. The resulting CSs were obtained as spherical agglomerates, with improved flowability. The compressibility study revealed an improved plastic deformation profile of RS, leading to better compaction and tensile strength. The presence of CCMS also ensured a rapid disintegration of the compressed tablets. CS-CCMS:SiO(2) (10:2.7), prepared with 10% CCMS, 2.7% silicon dioxide, and 40% solid content, was found to exhibit the best characteristics. Compared to the two commercial DC excipients, Prosolv(®) and Tablettose(®), the flow property of CS-CCMS:SiO(2) (10:2.7) was not significantly different, while the tensile strength was 23%: lower than that of Prosolv(®) but 4 times higher than that of Tablettose(®) at 196 MPa compression force. The disintegration time of CS-CCMS:SiO(2) (10:2.7) tablet (28 s) was practically identical to that of Tablettose(®) tablet (26 s) and far superior to that of Prosolv(®) tablet (>30 min). These results show that CSs could potentially be employed as a multifunctional excipient for the manufacturing of commercial tablets by DC. MDPI 2020-06-06 /pmc/articles/PMC7355677/ /pubmed/32517241 http://dx.doi.org/10.3390/pharmaceutics12060518 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trisopon, Karnkamol
Kittipongpatana, Nisit
Kittipongpatana, Ornanong Suwannapakul
A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression
title A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression
title_full A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression
title_fullStr A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression
title_full_unstemmed A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression
title_short A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression
title_sort spray-dried, co-processed rice starch as a multifunctional excipient for direct compression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355677/
https://www.ncbi.nlm.nih.gov/pubmed/32517241
http://dx.doi.org/10.3390/pharmaceutics12060518
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