The English (H6R) Mutation of the Alzheimer’s Disease Amyloid-β Peptide Modulates Its Zinc-Induced Aggregation

The coordination of zinc ions by histidine residues of amyloid-beta peptide (Aβ) plays a critical role in the zinc-induced Aβ aggregation implicated in Alzheimer’s disease (AD) pathogenesis. The histidine to arginine substitution at position 6 of the Aβ sequence (H6R, English mutation) leads to an e...

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Detalles Bibliográficos
Autores principales: Radko, Sergey P., Khmeleva, Svetlana A., Kaluzhny, Dmitry N., Kechko, Olga I., Kiseleva, Yana Y., Kozin, Sergey A., Mitkevich, Vladimir A., Makarov, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355780/
https://www.ncbi.nlm.nih.gov/pubmed/32630528
http://dx.doi.org/10.3390/biom10060961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355780/
https://www.ncbi.nlm.nih.gov/pubmed/32630528
http://dx.doi.org/10.3390/biom10060961

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