Prolyl Endopeptidase-Like Facilitates the α-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF

The aggregation of α-synuclein (α-Syn) is a characteristic of Parkinson’s disease (PD). α-Syn oligomerization/aggregation is accelerated by the serine peptidase, prolyl oligopeptidase (POP). Factors that affect POP conformation, including most of its inhibitors and an impairing mutation in its activ...

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Detalles Bibliográficos
Autores principales: Santos, Gabriel S., Oyadomari, William Y., Carvalho, Elizangela A., Torquato, Ricardo S., Oliveira, Vitor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355856/
https://www.ncbi.nlm.nih.gov/pubmed/32630529
http://dx.doi.org/10.3390/biom10060962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355856/
https://www.ncbi.nlm.nih.gov/pubmed/32630529
http://dx.doi.org/10.3390/biom10060962

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