Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2

While aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a tumor suppressor, its exon 2-depleted splice variant (AIMP2-DX2 or shortly DX2) is highly expressed in human lung cancer, and the ratio of DX2 to AIMP2 increases according to the progression of lung cancer. In this st...

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Detalles Bibliográficos
Autores principales: Kim, Dae Gyu, Park, Chul Min, Huddar, Srigouri, Lim, Semi, Kim, Sunghoon, Lee, Sunkyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355952/
https://www.ncbi.nlm.nih.gov/pubmed/32549310
http://dx.doi.org/10.3390/molecules25122763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355952/
https://www.ncbi.nlm.nih.gov/pubmed/32549310
http://dx.doi.org/10.3390/molecules25122763

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