Formulation and Optimization of Avanafil Biodegradable Polymeric Nanoparticles: A Single-Dose Clinical Pharmacokinetic Evaluation

Avanafil (AVA) is a second-generation phosphodiesterase-5 (PDE5) inhibitor. AVA shows high selectivity to penile tissues and fast absorption, but has a bioavailability of about 36%. The aim was to formulate and optimize AVA-biodegradable nanoparticles (NPs) to enhance AVA bioavailability. To assess...

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Detalles Bibliográficos
Autores principales: Aldawsari, Hibah M., Fahmy, Usama A., Abd-Allah, Fathy, Ahmed, Osama A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356025/
https://www.ncbi.nlm.nih.gov/pubmed/32604853
http://dx.doi.org/10.3390/pharmaceutics12060596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356025/
https://www.ncbi.nlm.nih.gov/pubmed/32604853
http://dx.doi.org/10.3390/pharmaceutics12060596

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