Development of 6′-N-Acylated Isepamicin Analogs with Improved Antibacterial Activity against Isepamicin-Resistant Pathogens

The development of new aminoglycoside (AG) antibiotics has been required to overcome the resistance mechanism of AG-modifying enzymes (AMEs) of AG-resistant pathogens. The AG acetyltransferase, AAC(6′)-APH(2″), one of the most typical AMEs, exhibiting substrate promiscuity towards a variety of AGs a...

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Detalles Bibliográficos
Autores principales: Ban, Yeon Hee, Song, Myoung Chong, Kim, Hee Jin, Lee, Heejeong, Wi, Jae Bok, Park, Je Won, Lee, Dong Gun, Yoon, Yeo Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356214/
https://www.ncbi.nlm.nih.gov/pubmed/32545254
http://dx.doi.org/10.3390/biom10060893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356214/
https://www.ncbi.nlm.nih.gov/pubmed/32545254
http://dx.doi.org/10.3390/biom10060893

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