Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation

Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB is a centrally acting drug that has a low oral bioavailability of 33% owing to its exposure to the hepatic first-p...

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Detalles Bibliográficos
Autores principales: Fahmy, Usama A., Badr-Eldin, Shaimaa M., Ahmed, Osama A. A., Aldawsari, Hibah M., Tima, Singkome, Asfour, Hani Z., Al-Rabia, Mohammed W., Negm, Aya A., Sultan, Muhammad H., Madkhali, Osama A. A., Alhakamy, Nabil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356232/
https://www.ncbi.nlm.nih.gov/pubmed/32471119
http://dx.doi.org/10.3390/pharmaceutics12060485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356232/
https://www.ncbi.nlm.nih.gov/pubmed/32471119
http://dx.doi.org/10.3390/pharmaceutics12060485

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