Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

Resistance to β-lactam antibacterials, importantly via production of β-lactamases, threatens their widespread use. Bicyclic boronates show promise as clinically useful, dual-action inhibitors of both serine- (SBL) and metallo- (MBL) β-lactamases. In combination with cefepime, the bicyclic boronate t...

Descripción completa

Detalles Bibliográficos
Autores principales: Lang, Pauline A., Parkova, Anete, Leissing, Thomas M., Calvopiña, Karina, Cain, Ricky, Krajnc, Alen, Panduwawala, Tharindi D., Philippe, Jules, Fishwick, Colin W. G., Trapencieris, Peteris, Page, Malcolm G. P., Schofield, Christopher J., Brem, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356297/
https://www.ncbi.nlm.nih.gov/pubmed/32545682
http://dx.doi.org/10.3390/biom10060899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356297/
https://www.ncbi.nlm.nih.gov/pubmed/32545682
http://dx.doi.org/10.3390/biom10060899

Ejemplares similares