Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study

Lower circulating homoarginine concentrations have been associated with morbidity and mortality in patients with established cardiovascular disease (CVD). We assayed plasma homoarginine concentrations in 3331 Framingham Offspring Study participants attending examination cycle six (mean age 58.6 year...

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Autores principales: Schwedhelm, Edzard, Song, Rebecca J., Vasan, Ramachandran S., van den Heuvel, Edwin R., Hannemann, Juliane, Xanthakis, Vanessa, Böger, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356383/
https://www.ncbi.nlm.nih.gov/pubmed/32604958
http://dx.doi.org/10.3390/jcm9062016
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author Schwedhelm, Edzard
Song, Rebecca J.
Vasan, Ramachandran S.
van den Heuvel, Edwin R.
Hannemann, Juliane
Xanthakis, Vanessa
Böger, Rainer
author_facet Schwedhelm, Edzard
Song, Rebecca J.
Vasan, Ramachandran S.
van den Heuvel, Edwin R.
Hannemann, Juliane
Xanthakis, Vanessa
Böger, Rainer
author_sort Schwedhelm, Edzard
collection PubMed
description Lower circulating homoarginine concentrations have been associated with morbidity and mortality in patients with established cardiovascular disease (CVD). We assayed plasma homoarginine concentrations in 3331 Framingham Offspring Study participants attending examination cycle six (mean age 58.6 years, 53% women). We evaluated correlates of plasma homoarginine and related homoarginine to incident CVD and death. We also classified participants as having higher (upper quartile) versus lower (lower three quartiles) homoarginine and previously assayed asymmetric dimethylarginine (ADMA) concentrations, and created cross-classification groups. We observed 630 incident CVD events and 940 deaths during a median follow-up of 18 years. In multivariable regression analysis, homoarginine was associated positively with male sex, body mass index, anti-hypertensive medication use and systolic blood pressure, but inversely with age and smoking. Higher homoarginine levels were associated with a lower mortality risk (hazard ratio (HR) per SD increment, 0.83, 95% CI: 0.74–0.93) adjusting for standard CVD risk factors, and ADMA. Among the cross-classification groups, participants with higher homoarginine and lower ADMA had a lower mortality risk (HR, 0.81, 95% CI: 0.67–0.98) compared to those with low levels of both. Further studies are needed to dissect the mechanisms of the association of homoarginine and mortality over decades in the community.
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spelling pubmed-73563832020-07-30 Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study Schwedhelm, Edzard Song, Rebecca J. Vasan, Ramachandran S. van den Heuvel, Edwin R. Hannemann, Juliane Xanthakis, Vanessa Böger, Rainer J Clin Med Article Lower circulating homoarginine concentrations have been associated with morbidity and mortality in patients with established cardiovascular disease (CVD). We assayed plasma homoarginine concentrations in 3331 Framingham Offspring Study participants attending examination cycle six (mean age 58.6 years, 53% women). We evaluated correlates of plasma homoarginine and related homoarginine to incident CVD and death. We also classified participants as having higher (upper quartile) versus lower (lower three quartiles) homoarginine and previously assayed asymmetric dimethylarginine (ADMA) concentrations, and created cross-classification groups. We observed 630 incident CVD events and 940 deaths during a median follow-up of 18 years. In multivariable regression analysis, homoarginine was associated positively with male sex, body mass index, anti-hypertensive medication use and systolic blood pressure, but inversely with age and smoking. Higher homoarginine levels were associated with a lower mortality risk (hazard ratio (HR) per SD increment, 0.83, 95% CI: 0.74–0.93) adjusting for standard CVD risk factors, and ADMA. Among the cross-classification groups, participants with higher homoarginine and lower ADMA had a lower mortality risk (HR, 0.81, 95% CI: 0.67–0.98) compared to those with low levels of both. Further studies are needed to dissect the mechanisms of the association of homoarginine and mortality over decades in the community. MDPI 2020-06-26 /pmc/articles/PMC7356383/ /pubmed/32604958 http://dx.doi.org/10.3390/jcm9062016 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schwedhelm, Edzard
Song, Rebecca J.
Vasan, Ramachandran S.
van den Heuvel, Edwin R.
Hannemann, Juliane
Xanthakis, Vanessa
Böger, Rainer
Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study
title Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study
title_full Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study
title_fullStr Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study
title_full_unstemmed Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study
title_short Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study
title_sort association of lower plasma homoarginine concentrations with greater risk of all-cause mortality in the community: the framingham offspring study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356383/
https://www.ncbi.nlm.nih.gov/pubmed/32604958
http://dx.doi.org/10.3390/jcm9062016
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