Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study
Lower circulating homoarginine concentrations have been associated with morbidity and mortality in patients with established cardiovascular disease (CVD). We assayed plasma homoarginine concentrations in 3331 Framingham Offspring Study participants attending examination cycle six (mean age 58.6 year...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356383/ https://www.ncbi.nlm.nih.gov/pubmed/32604958 http://dx.doi.org/10.3390/jcm9062016 |
_version_ | 1783558486578167808 |
---|---|
author | Schwedhelm, Edzard Song, Rebecca J. Vasan, Ramachandran S. van den Heuvel, Edwin R. Hannemann, Juliane Xanthakis, Vanessa Böger, Rainer |
author_facet | Schwedhelm, Edzard Song, Rebecca J. Vasan, Ramachandran S. van den Heuvel, Edwin R. Hannemann, Juliane Xanthakis, Vanessa Böger, Rainer |
author_sort | Schwedhelm, Edzard |
collection | PubMed |
description | Lower circulating homoarginine concentrations have been associated with morbidity and mortality in patients with established cardiovascular disease (CVD). We assayed plasma homoarginine concentrations in 3331 Framingham Offspring Study participants attending examination cycle six (mean age 58.6 years, 53% women). We evaluated correlates of plasma homoarginine and related homoarginine to incident CVD and death. We also classified participants as having higher (upper quartile) versus lower (lower three quartiles) homoarginine and previously assayed asymmetric dimethylarginine (ADMA) concentrations, and created cross-classification groups. We observed 630 incident CVD events and 940 deaths during a median follow-up of 18 years. In multivariable regression analysis, homoarginine was associated positively with male sex, body mass index, anti-hypertensive medication use and systolic blood pressure, but inversely with age and smoking. Higher homoarginine levels were associated with a lower mortality risk (hazard ratio (HR) per SD increment, 0.83, 95% CI: 0.74–0.93) adjusting for standard CVD risk factors, and ADMA. Among the cross-classification groups, participants with higher homoarginine and lower ADMA had a lower mortality risk (HR, 0.81, 95% CI: 0.67–0.98) compared to those with low levels of both. Further studies are needed to dissect the mechanisms of the association of homoarginine and mortality over decades in the community. |
format | Online Article Text |
id | pubmed-7356383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73563832020-07-30 Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study Schwedhelm, Edzard Song, Rebecca J. Vasan, Ramachandran S. van den Heuvel, Edwin R. Hannemann, Juliane Xanthakis, Vanessa Böger, Rainer J Clin Med Article Lower circulating homoarginine concentrations have been associated with morbidity and mortality in patients with established cardiovascular disease (CVD). We assayed plasma homoarginine concentrations in 3331 Framingham Offspring Study participants attending examination cycle six (mean age 58.6 years, 53% women). We evaluated correlates of plasma homoarginine and related homoarginine to incident CVD and death. We also classified participants as having higher (upper quartile) versus lower (lower three quartiles) homoarginine and previously assayed asymmetric dimethylarginine (ADMA) concentrations, and created cross-classification groups. We observed 630 incident CVD events and 940 deaths during a median follow-up of 18 years. In multivariable regression analysis, homoarginine was associated positively with male sex, body mass index, anti-hypertensive medication use and systolic blood pressure, but inversely with age and smoking. Higher homoarginine levels were associated with a lower mortality risk (hazard ratio (HR) per SD increment, 0.83, 95% CI: 0.74–0.93) adjusting for standard CVD risk factors, and ADMA. Among the cross-classification groups, participants with higher homoarginine and lower ADMA had a lower mortality risk (HR, 0.81, 95% CI: 0.67–0.98) compared to those with low levels of both. Further studies are needed to dissect the mechanisms of the association of homoarginine and mortality over decades in the community. MDPI 2020-06-26 /pmc/articles/PMC7356383/ /pubmed/32604958 http://dx.doi.org/10.3390/jcm9062016 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schwedhelm, Edzard Song, Rebecca J. Vasan, Ramachandran S. van den Heuvel, Edwin R. Hannemann, Juliane Xanthakis, Vanessa Böger, Rainer Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study |
title | Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study |
title_full | Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study |
title_fullStr | Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study |
title_full_unstemmed | Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study |
title_short | Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study |
title_sort | association of lower plasma homoarginine concentrations with greater risk of all-cause mortality in the community: the framingham offspring study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356383/ https://www.ncbi.nlm.nih.gov/pubmed/32604958 http://dx.doi.org/10.3390/jcm9062016 |
work_keys_str_mv | AT schwedhelmedzard associationoflowerplasmahomoarginineconcentrationswithgreaterriskofallcausemortalityinthecommunitytheframinghamoffspringstudy AT songrebeccaj associationoflowerplasmahomoarginineconcentrationswithgreaterriskofallcausemortalityinthecommunitytheframinghamoffspringstudy AT vasanramachandrans associationoflowerplasmahomoarginineconcentrationswithgreaterriskofallcausemortalityinthecommunitytheframinghamoffspringstudy AT vandenheuveledwinr associationoflowerplasmahomoarginineconcentrationswithgreaterriskofallcausemortalityinthecommunitytheframinghamoffspringstudy AT hannemannjuliane associationoflowerplasmahomoarginineconcentrationswithgreaterriskofallcausemortalityinthecommunitytheframinghamoffspringstudy AT xanthakisvanessa associationoflowerplasmahomoarginineconcentrationswithgreaterriskofallcausemortalityinthecommunitytheframinghamoffspringstudy AT bogerrainer associationoflowerplasmahomoarginineconcentrationswithgreaterriskofallcausemortalityinthecommunitytheframinghamoffspringstudy |