Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using a Horner–Wadsworth–Emmons-based approach

Integrin inhibitors based on the tripeptide sequence Arg–Gly–Asp (RGD) are potential therapeutics for the treatment of idiopathic pulmonary fibrosis (IPF). Herein, we describe an expeditious three-step synthetic sequence of Horner–Wadsworth–Emmons olefination, diimide reduction, and global deprotect...

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Detalles Bibliográficos
Autores principales: Lippa, Rhys A, Murphy, John A, Barrett, Tim N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356399/
https://www.ncbi.nlm.nih.gov/pubmed/32704328
http://dx.doi.org/10.3762/bjoc.16.134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356399/
https://www.ncbi.nlm.nih.gov/pubmed/32704328
http://dx.doi.org/10.3762/bjoc.16.134

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