Targeting Activated Hepatic Stellate Cells Using Collagen-Binding Chitosan Nanoparticles for siRNA Delivery to Fibrotic Livers

Activated hepatic stellate cells (aHSCs) are the main orchestrators of the fibrotic cascade in inflamed livers, with transforming growth factor-beta (TGF-β) being the most potent pro-fibrotic cytokine. Hence, aHSCs serve as interesting therapeutic targets. However, drug delivery to aHSCs is hindered...

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Detalles Bibliográficos
Autores principales: Azzam, Menna, El Safy, Sara, Abdelgelil, Sarah A., Weiskirchen, Ralf, Asimakopoulou, Anastasia, de Lorenzi, Federica, Lammers, Twan, Mansour, Samar, Tammam, Salma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356502/
https://www.ncbi.nlm.nih.gov/pubmed/32630415
http://dx.doi.org/10.3390/pharmaceutics12060590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356502/
https://www.ncbi.nlm.nih.gov/pubmed/32630415
http://dx.doi.org/10.3390/pharmaceutics12060590

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