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Methylpiperidinopyrazole Attenuates Estrogen-Induced Mitochondrial Energy Production and Subsequent Osteoblast Maturation via an Estrogen Receptor Alpha-Dependent Mechanism
An estrogen deficiency is the main cause of osteoporosis in postmenopausal women. In bone remodeling, estrogen receptors (ERs) can mediate estrogen-transducing signals. Methylpiperidinopyrazole (MPP) is a highly specific antagonist of ER-alpha (ERα). This study was designed to evaluate the effects o...
Autores principales: | Yeh, Poh-Shiow, Chen, Jui-Tai, Cherng, Yih-Giun, Yang, Shun-Tai, Tai, Yu-Ting, Chen, Ruei-Ming |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356510/ https://www.ncbi.nlm.nih.gov/pubmed/32580515 http://dx.doi.org/10.3390/molecules25122876 |
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