Fibrillization of 40-residue β-Amyloid Peptides in Membrane-Like Environments Leads to Different Fibril Structures and Reduced Molecular Polymorphisms

The molecular-level polymorphism in β-Amyloid (Aβ) fibrils have recently been considered as a pathologically relevant factor in Alzheimer’s disease (AD). Studies showed that the structural deviations in human-brain-seeded Aβ fibrils potentially correlated with the clinical histories of AD patients....

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Detalles Bibliográficos
Autores principales: Cheng, Qinghui, Hu, Zhi-Wen, Tobin-Miyaji, Yuto, Perkins, Amy E., Deak, Terrence, Qiang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356566/
https://www.ncbi.nlm.nih.gov/pubmed/32521743
http://dx.doi.org/10.3390/biom10060881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356566/
https://www.ncbi.nlm.nih.gov/pubmed/32521743
http://dx.doi.org/10.3390/biom10060881

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