Cargando…

Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents

In this paper, synthesis and antimicrobial studies of 31 novel coumarin-substituted pyrazole derivatives are reported. Some of these compounds have shown potent activity against methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration (MIC) as low as 3.125 µg/mL. Thes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alnufaie, Rawan, Raj KC, Hansa, Alsup, Nickolas, Whitt, Jedidiah, Andrew Chambers, Steven, Gilmore, David, Alam, Mohammad A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356691/ https://www.ncbi.nlm.nih.gov/pubmed/32549248 http://dx.doi.org/10.3390/molecules25122758

Ejemplares similares

Design, and Synthesis of 4-[4-Formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic Acid Derivatives as Potent Growth Inhibitors of Drug-Resistant Staphylococcus aureus.
por: Alnufaie, Rawan, et al.
Publicado: (2020)

Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistant Staphylococcus aureus and Acinetobacter baumannii
por: Whitt, Jedidiah, et al.
Publicado: (2019)

Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria
por: Alkhaibari, Ibrahim S., et al.
Publicado: (2021)

Development of 4-[4-(Anilinomethyl)-3-phenyl-pyrazol-1-yl] Benzoic Acid Derivatives as Potent Anti-Staphylococci and Anti-Enterococci Agents
por: Raj KC, Hansa, et al.
Publicado: (2022)

Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
por: Whitt, Jedidiah, et al.
Publicado: (2019)

Synthesis of 4,4′-(4-Formyl-1H-pyrazole-1,3-diyl)dibenzoic Acid Derivatives as Narrow Spectrum Antibiotics for the Potential Treatment of Acinetobacter Baumannii Infections
por: Delancey, Evan, et al.
Publicado: (2020)

Modulation of Drug Resistance in Staphylococcus aureus with Coumarin Derivatives
por: de Araújo, Rodrigo Santos Aquino, et al.
Publicado: (2016)

Hexafluoroisopropanol-Mediated Domino Reaction for the Synthesis of Thiazolo-androstenones: Potent Anticancer Agents
por: Okolo, ChrisTina, et al.
Publicado: (2018)

A QSAR Study on the 4-Substituted Coumarins as Potent Tubulin Polymerization Inhibitors
por: Dinparast, Leila, et al.
Publicado: (2020)

Coumarin-Encapsulated Solid Lipid Nanoparticles as an Effective Therapy against Methicillin-Resistant Staphylococcus aureus
por: Alqarni, Mohammed H., et al.
Publicado: (2022)

Synthesis and antimicrobial activity of new series of thiazoles, pyridines and pyrazoles based on coumarin moiety
por: Sayed, Mariam T., et al.
Publicado: (2023)

C-3- and C-4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors
por: Ganeshapillai, Dharshini, et al.
Publicado: (2018)

Site-Specific Evaluation of Bioactive Coumarin-Loaded Dendrimer G4 Nanoparticles against Methicillin Resistant Staphylococcus aureus
por: Foudah, Ahmed I., et al.
Publicado: (2022)

CBPDdb: a curated database of compounds derived from Coumarin–Benzothiazole–Pyrazole
por: Rampogu, Shailima, et al.
Publicado: (2023)

Therapeutic Effects of Coumarins with Different Substitution Patterns
por: Flores-Morales, Virginia, et al.
Publicado: (2023)

The changing epidemiology of Staphylococcus aureus?
por: Chambers, H F
Publicado: (2001)

Study of Coumarin-Resveratrol Hybrids as Potent Antioxidant Compounds
por: Matos, Maria J., et al.
Publicado: (2015)

New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus
por: Talia, Juan Manuel, et al.
Publicado: (2011)

Enaminones as Building Blocks for the Synthesis of Substituted Pyrazoles with Antitumor and Antimicrobial Activities
por: Riyadh, Sayed M.
Publicado: (2011)

Antimicrobial screening to molecular docking of newly synthesized ferrocenyl-substituted pyrazole
por: Sharma, Shashi, et al.
Publicado: (2022)

A new coumarin compound DCH combats methicillin-resistant Staphylococcus aureus biofilm by targeting arginine repressor
por: Qu, Di, et al.
Publicado: (2020)

Photolabile coumarins with improved efficiency through azetidinyl substitution
por: Bassolino, Giovanni, et al.
Publicado: (2017)

Spectral Properties of Substituted Coumarins in Solution and Polymer Matrices
por: Donovalová, Jana, et al.
Publicado: (2012)

Synthesis and Antimicrobial Activity of 4-Substituted 1,2,3-Triazole-Coumarin Derivatives
por: López-Rojas, Priscila, et al.
Publicado: (2018)

Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates
por: Wu, Hua, et al.
Publicado: (2012)

Prevalence of Methicillin-Resistant Staphylococcus aureus in Shrines
por: Arjyal, Charu, et al.
Publicado: (2020)

Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives
por: Niinivehmas, Sanna, et al.
Publicado: (2018)

Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing
por: Karathanasi, Georgia, et al.
Publicado: (2018)

Molecular docking and inhibition studies on the interactions of Bacopa monnieri’s potent phytochemicals against pathogenic Staphylococcus aureus
por: Emran, Talha Bin, et al.
Publicado: (2015)

Ultrasound Promoted Synthesis of Bis(substituted pyrazol-4-ylcarbonyl)-Substituted Thioureas
por: Xiao, Li, et al.
Publicado: (2009)

Design and Synthesis of Small Molecules as Potent Staphylococcus aureus Sortase A Inhibitors
por: Ha, Min Woo, et al.
Publicado: (2020)

Revisiting the Structure and Chemistry of 3(5)-Substituted Pyrazoles
por: Secrieru, Alina, et al.
Publicado: (2019)

Antimalarial Activity of Tri- and Tetra-Substituted Anilino Pyrazoles
por: Lusardi, Matteo, et al.
Publicado: (2023)

Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia
por: Choo, Eun Ju, et al.
Publicado: (2016)

Microwave-assisted synthesis, computational studies and antibacterial/ anti-inflammatory activities of compounds based on coumarin-pyrazole hybrid
por: Chavan, Rakesh R., et al.
Publicado: (2018)

Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin—resistant Staphylococcus aureus
por: Johnston, Tatiana, et al.
Publicado: (2018)

Crystal structures of three 6-substituted coumarin-3-carboxamide derivatives
por: Gomes, Lígia R., et al.
Publicado: (2016)

Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivatives
por: Katopodi, Annita, et al.
Publicado: (2021)

Design of potent fluoro-substituted chalcones as antimicrobial agents
por: Burmaoglu, Serdar, et al.
Publicado: (2017)

Effect Of Galbanic Acid, A Sesquiterpene Coumarin From Ferula Szowitsiana, As An Inhibitor Of Efflux Mechanism In Resistant Clinical Isolates Of Staphylococcus Aureus
por: Bazzaz, Bibi Sedigheh Fazly, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_39o59r8ku3pi5agtvg34hdv3iu