Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells

Synthetic pyrrole-imidazole (PI) polyamides bind to the minor groove of double-helical DNA with high affinity and specificity, and inhibit the transcription of corresponding genes. In liver cancer, transforming growth factor (TGF)-β expression is correlated with tumor grade, and high-grade liver can...

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Detalles Bibliográficos
Autores principales: Takagi, Keiko, Midorikawa, Yutaka, Takayama, Tadatoshi, Abe, Hayato, Fujiwara, Kyoko, Soma, Masayoshi, Nagase, Hiroki, Miki, Toshio, Fukuda, Noboru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356887/
https://www.ncbi.nlm.nih.gov/pubmed/32585841
http://dx.doi.org/10.3390/molecules25122883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356887/
https://www.ncbi.nlm.nih.gov/pubmed/32585841
http://dx.doi.org/10.3390/molecules25122883

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