1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

A series of Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors based on a reported compound 3 were synthesized and evaluated for their capacity to inhibit MtbTMPK catalytic activity and the growth of a virulent M. tuberculosis strain (H37Rv). Modifications of the scaffold of 3 failed to afford sub...

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Detalles Bibliográficos
Autores principales: Jian, Yanlin, Hulpia, Fabian, D. P. Risseeuw, Martijn, Forbes, He Eun, Caljon, Guy, Munier-Lehmann, Hélène, I. M. Boshoff, Helena, Van Calenbergh, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356956/
https://www.ncbi.nlm.nih.gov/pubmed/32560578
http://dx.doi.org/10.3390/molecules25122805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356956/
https://www.ncbi.nlm.nih.gov/pubmed/32560578
http://dx.doi.org/10.3390/molecules25122805

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