Cargando…

The Performance of Gene Expression Signature-Guided Drug–Disease Association in Different Categories of Drugs and Diseases

A gene expression signature (GES) is a group of genes that shows a unique expression profile as a result of perturbations by drugs, genetic modification or diseases on the transcriptional machinery. The comparisons between GES profiles have been used to investigate the relationships between drugs, t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qi, Xiguang, Shen, Mingzhe, Fan, Peihao, Guo, Xiaojiang, Wang, Tianqi, Feng, Ning, Zhang, Manling, Sweet, Robert A., Kirisci, Levent, Wang, Lirong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357095/ https://www.ncbi.nlm.nih.gov/pubmed/32560162 http://dx.doi.org/10.3390/molecules25122776

Ejemplares similares

Prediction of Suicide-Related Events by Analyzing Electronic Medical Records from PTSD Patients with Bipolar Disorder
por: Fan, Peihao, et al.
Publicado: (2020)

Network Systems Pharmacology-Based Mechanism Study on the Beneficial Effects of Vitamin D against Psychosis in Alzheimer’s Disease
por: Fan, Peihao, et al.
Publicado: (2020)

Prediction of Adverse Events Risk in Patients with Comorbid Post- Traumatic Stress Disorder and Alcohol Use Disorder Using Electronic Medical Records by Deep Learning Models
por: Miranda, Oshin, et al.
Publicado: (2023)

DeepBiomarker2: Prediction of alcohol and substance use disorder risk in post-traumatic stress disorder patients using electronic medical records and multiple social determinants of health
por: Miranda, Oshin, et al.
Publicado: (2023)

Unveiling the Enigma: Exploring Risk Factors and Mechanisms for Psychotic Symptoms in Alzheimer’s Disease through Electronic Medical Records with Deep Learning Models
por: Fan, Peihao, et al.
Publicado: (2023)

An Emulation of Randomized Trials of Administrating Antipsychotics in PTSD Patients for Outcomes of Suicide-Related Events
por: Delapaz, Noah R., et al.
Publicado: (2021)

An Emulation of Randomized Trials of Administrating Benzodiazepines in PTSD Patients for Outcomes of Suicide-Related Events
por: Gilbert, Michael, et al.
Publicado: (2020)

Effect of ondansetron on reducing ICU mortality in patients with acute kidney injury
por: Guo, Xiaojiang, et al.
Publicado: (2021)

Synergism of antihypertensives and cholinesterase inhibitors in Alzheimer's disease
por: Hu, Ziheng, et al.
Publicado: (2018)

Combination of antidepressants and antipsychotics as a novel treatment option for psychosis in Alzheimer's disease
por: Fan, Peihao, et al.
Publicado: (2023)

DeepBiomarker: Identifying Important Lab Tests from Electronic Medical Records for the Prediction of Suicide-Related Events among PTSD Patients
por: Miranda, Oshin, et al.
Publicado: (2022)

Drug Use Disorders and Violence: Associations With Individual Drug Categories
por: Zhong, Shaoling, et al.
Publicado: (2020)

Data Mining and Machine Learning Models for Predicting Drug Likeness and Their Disease or Organ Category
por: Yosipof, Abraham, et al.
Publicado: (2018)

Investigating the Relative Significance of Drug-Related Problem Categories
por: Kjeldsen, Lene Juel, et al.
Publicado: (2017)

Oncology drugs for orphan indications: how are HTA processes evolving for this specific drug category?
por: Adkins, Elizabeth M, et al.
Publicado: (2017)

Assessment of Satisfaction with Drug Provision of Antihypertensive Drugs at the Outpatient Level of Privileged Categories of Residens
por: Jamil, Abuov, et al.
Publicado: (2022)

Cardiovascular Disease Chemogenomics Knowledgebase-guided Target Identification and Drug Synergy Mechanism Study of an Herbal Formula
por: Zhang, Hai, et al.
Publicado: (2016)

Procedural-based category learning in patients with Parkinson's disease: impact of category number and category continuity
por: Filoteo, J. Vincent, et al.
Publicado: (2014)

Comprehensive characterization of a drug-resistance-related ceRNA network across 15 anti-cancer drug categories
por: Liu, Bing, et al.
Publicado: (2021)

Category C Diseases and Agents
por: Ryan, Jeffrey R.
Publicado: (2016)

Military Categories in Diseases of the Ear
Publicado: (1919)

Multiscale Modeling of Drug-induced Effects of ReDuNing Injection on Human Disease: From Drug Molecules to Clinical Symptoms of Disease
por: Luo, Fang, et al.
Publicado: (2015)

Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug
por: Lee, Hee Sook, et al.
Publicado: (2012)

Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy
por: Wu, Manling, et al.
Publicado: (2022)

Drug and disease signature integration identifies synergistic combinations in glioblastoma
por: Stathias, Vasileios, et al.
Publicado: (2018)

Disease, Drugs and Dysbiosis: Understanding Microbial Signatures in Metabolic Disease and Medical Interventions
por: Proffitt, Ceri, et al.
Publicado: (2020)

Biomarker-guided drug therapy: personalized medicine for treating Alzheimer’s disease
por: Syal, Charvi, et al.
Publicado: (2021)

Comparison of drug-eluting balloon with repeat drug-eluting stent for recurrent drug-eluting stent in-stent restenosis
por: Wang, Guozhong, et al.
Publicado: (2019)

A Comparative Study on the Cost of New Antibiotics and Drugs of Other Therapeutic Categories
por: Falagas, Matthew E., et al.
Publicado: (2006)

Category and Perceptual Learning in Subjects with Treated Wilson's Disease
por: Xu, Pengjing, et al.
Publicado: (2010)

Association of Early and Supernormal Vascular Aging categories with cardiovascular disease in the Chinese population
por: Cao, Qiuyu, et al.
Publicado: (2022)

Causal reasoning over knowledge graphs leveraging drug-perturbed and disease-specific transcriptomic signatures for drug discovery
por: Domingo-Fernández, Daniel, et al.
Publicado: (2022)

Differential Seasonality of Legionnaires’ Disease by Exposure Category
por: Buchholz, Udo, et al.
Publicado: (2020)

Exact categories and categories of sheaves
por: Barr, Michael, et al.
Publicado: (1971)

CVDHD: a cardiovascular disease herbal database for drug discovery and network pharmacology
por: Gu, Jiangyong, et al.
Publicado: (2013)

Identification of Novel Reference Genes Based on MeSH Categories
por: Ersahin, Tulin, et al.
Publicado: (2014)

Identification of Prognostic Signature and Gliclazide as Candidate Drugs in Lung Adenocarcinoma
por: Cheng, Yang, et al.
Publicado: (2021)

Widespread signatures of natural selection across human complex traits and functional genomic categories
por: Zeng, Jian, et al.
Publicado: (2021)

Chemical signatures and new drug targets for gametocytocidal drug development
por: Sun, Wei, et al.
Publicado: (2014)

Image Guided Biodistribution of Drugs and Drug Delivery
por: Ding, Hong, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_nbdkt1il64u21utae7hhl9ej42