Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis

Despite the use of various pharmacotherapeutic strategies, fibrosis due to nonalcoholic steatohepatitis (NASH) remains an unsatisfied clinical issue. We investigated the effect of sevelamer, a hydrophilic bile acid sequestrant, on hepatic fibrosis in a murine NASH model. Male C57BL/6J mice were fed...

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Detalles Bibliográficos
Autores principales: Tsuji, Yuki, Kaji, Kosuke, Kitade, Mitsuteru, Kaya, Daisuke, Kitagawa, Koh, Ozutsumi, Takahiro, Fujinaga, Yukihisa, Takaya, Hiroaki, Kawaratani, Hideto, Namisaki, Tadashi, Moriya, Kei, Akahane, Takemi, Yoshiji, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357162/
https://www.ncbi.nlm.nih.gov/pubmed/32575352
http://dx.doi.org/10.3390/microorganisms8060925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357162/
https://www.ncbi.nlm.nih.gov/pubmed/32575352
http://dx.doi.org/10.3390/microorganisms8060925

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