Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene psen2

PRESENILIN 2 (PSEN2) is one of the genes mutated in early onset familial Alzheimer’s disease (EOfAD). PSEN2 shares significant amino acid sequence identity with another EOfAD-related gene PRESENILIN 1 (PSEN1), and partial functional redundancy is seen between these two genes. However, the complete r...

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Detalles Bibliográficos
Autores principales: Jiang, Haowei, Pederson, Stephen Martin, Newman, Morgan, Dong, Yang, Barthelson, Karissa, Lardelli, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357760/
https://www.ncbi.nlm.nih.gov/pubmed/32658922
http://dx.doi.org/10.1371/journal.pone.0232559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357760/
https://www.ncbi.nlm.nih.gov/pubmed/32658922
http://dx.doi.org/10.1371/journal.pone.0232559

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