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腺相关病毒包装条件优化及重组AAV8/hFⅧ基因治疗血友病A小鼠的实验研究

OBJECTIVE: To evaluate the effects of adeno-associated virus (AAV) carrying hFⅧ by serotype 8 (AAV8/hFⅧ) on hemophilia A (HA) mice by gene therapy strategy. METHODS: pAAV-CB-EGFP, pH22 (serotype 2) and pfΔ6 (adenovirus helper) were used to package AAV into HEK-293 cells in different conditions (rati...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial office of Chinese Journal of Hematology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357902/
https://www.ncbi.nlm.nih.gov/pubmed/32023752
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.01.007