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腺相关病毒包装条件优化及重组AAV8/hFⅧ基因治疗血友病A小鼠的实验研究
OBJECTIVE: To evaluate the effects of adeno-associated virus (AAV) carrying hFⅧ by serotype 8 (AAV8/hFⅧ) on hemophilia A (HA) mice by gene therapy strategy. METHODS: pAAV-CB-EGFP, pH22 (serotype 2) and pfΔ6 (adenovirus helper) were used to package AAV into HEK-293 cells in different conditions (rati...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
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Editorial office of Chinese Journal of Hematology
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357902/ https://www.ncbi.nlm.nih.gov/pubmed/32023752 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.01.007 |