Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes

Cytochrome P450 46A1 encoded by CYP46A1 catalyzes cholesterol 24-hydroxylation and is a CNS-specific enzyme that controls cholesterol removal and turnover in the brain. Accumulating data suggest that increases in cytochrome P450 46A1 activity in mouse models of common neurodegenerative diseases affe...

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Detalles Bibliográficos
Autores principales: Petrov, Alexey M, Mast, Natalia, Li, Young, Denker, John, Pikuleva, Irina A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357967/
https://www.ncbi.nlm.nih.gov/pubmed/32661514
http://dx.doi.org/10.1093/braincomms/fcaa043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357967/
https://www.ncbi.nlm.nih.gov/pubmed/32661514
http://dx.doi.org/10.1093/braincomms/fcaa043

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