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Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes
Cytochrome P450 46A1 encoded by CYP46A1 catalyzes cholesterol 24-hydroxylation and is a CNS-specific enzyme that controls cholesterol removal and turnover in the brain. Accumulating data suggest that increases in cytochrome P450 46A1 activity in mouse models of common neurodegenerative diseases affe...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357967/ https://www.ncbi.nlm.nih.gov/pubmed/32661514 http://dx.doi.org/10.1093/braincomms/fcaa043 |