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Bayesian central statistical monitoring using finite mixture models in multicenter clinical trials
BACKGROUND: Central monitoring (CM), in which data across all clinical sites are monitored, has an important role in risk-based monitoring. Several statistical methods have been proposed to compare patient outcomes among the sites for detecting atypical sites that have different trends in observed d...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358264/ https://www.ncbi.nlm.nih.gov/pubmed/32685763 http://dx.doi.org/10.1016/j.conctc.2020.100566 |