An in situ Gelling System Based on Methylcellulose and Tranilast Solid Nanoparticles Enhances Ocular Residence Time and Drug Absorption Into the Cornea and Conjunctiva

We previously developed ophthalmic formulations containing tranilast nanopartaicles (ophthalmic TL-NPs formulations), and found them to show high uptake into ocular tissues. In this study, we aimed to design an in situ gel incorporating TL-NPs with 0.5–3% methylcellulose (MC, type SM-4) to ensure lo...

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Detalles Bibliográficos
Autores principales: Nagai, Noriaki, Minami, Misa, Deguchi, Saori, Otake, Hiroko, Sasaki, Hiroshi, Yamamoto, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358604/
https://www.ncbi.nlm.nih.gov/pubmed/32733870
http://dx.doi.org/10.3389/fbioe.2020.00764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358604/
https://www.ncbi.nlm.nih.gov/pubmed/32733870
http://dx.doi.org/10.3389/fbioe.2020.00764

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