Expanding the Structural Diversity of Drimentines by Exploring the Promiscuity of Two N-methyltransferases

Methylation is envisioned as a promising way to rationally improve key pharmacokinetic characteristics of lead compounds. Although diverse tailoring enzymes are found to be clustered with cyclodipeptide synthases (CDPSs) to perform further modification reactions on the diketopiperazine (DKP) rings g...

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Detalles Bibliográficos
Autores principales: Yao, Tingting, Liu, Jing, Jin, Enjing, Liu, Zengzhi, Li, Huayue, Che, Qian, Zhu, Tianjiao, Li, Dehai, Li, Wenli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358741/
https://www.ncbi.nlm.nih.gov/pubmed/32659721
http://dx.doi.org/10.1016/j.isci.2020.101323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358741/
https://www.ncbi.nlm.nih.gov/pubmed/32659721
http://dx.doi.org/10.1016/j.isci.2020.101323

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