Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis

Rationale: Loss of iron-sulfur cluster function predisposes cancer cells to ferroptosis by upregulating iron-starvation response, but the role of glutaredoxin 5 (GLRX5) silencing in ferroptosis remains unknown. We examined the role of GLRX5 functional loss in promoting ferroptosis in cisplatin-resis...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jaewang, You, Ji Hyeon, Shin, Daiha, Roh, Jong-Lyel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359084/
https://www.ncbi.nlm.nih.gov/pubmed/32685019
http://dx.doi.org/10.7150/thno.46903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359084/
https://www.ncbi.nlm.nih.gov/pubmed/32685019
http://dx.doi.org/10.7150/thno.46903

Ejemplares similares