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Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures

With the help of novel processing workflows and algorithms, we have obtained a better understanding of the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state. We have re-analyzed previous cryo-EM data combining 3D clustering approaches with ways to explore a conti...

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Detalles Bibliográficos
Autores principales: Melero, Roberto, Sorzano, Carlos Oscar S., Foster, Brent, Vilas, José-Luis, Martínez, Marta, Marabini, Roberto, Ramírez-Aportela, Erney, Sanchez-Garcia, Ruben, Herreros, David, del Caño, Laura, Losana, Patricia, Fonseca-Reyna, Yunior C., Conesa, Pablo, Wrapp, Daniel, Chacon, Pablo, McLellan, Jason S., Tagare, Hemant D., Carazo, Jose-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359526/
https://www.ncbi.nlm.nih.gov/pubmed/32676604
http://dx.doi.org/10.1101/2020.07.08.191072