Cargando…

CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer’s disease as an indicator of tau phosphorylation

BACKGROUND: Recently, several studies suggested potential involvements of α-synuclein in Alzheimer’s disease (AD) pathophysiology. Higher concentrations of α-synuclein were reported in cerebrospinal fluid (CSF) of AD patients with a positive correlation towards CSF tau, indicating its possible role...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shim, Kyu Hwan, Kang, Min Ju, Suh, Jee Won, Pyun, Jung-Min, Ryoo, Nayoung, Park, Young Ho, Youn, Young Chul, Jang, Jae-Won, Jeong, Jee Hyang, Park, Kyung Won, Choi, Seong Hye, Suk, Kyoungho, Lee, Ho-Won, Ko, Pan-Woo, Lee, Chan-Nyoung, Lim, Tae-Sung, An, Seong Soo A., Kim, SangYun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359621/ https://www.ncbi.nlm.nih.gov/pubmed/32660565 http://dx.doi.org/10.1186/s13195-020-00648-9

Ejemplares similares

Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer’s disease
por: Shim, Kyu Hwan, et al.
Publicado: (2022)

Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer’s disease
por: Youn, Young Chul, et al.
Publicado: (2019)

Increased CSF tau level is correlated with decreased lamina cribrosa thickness
por: Lee, Eun Ji, et al.
Publicado: (2016)

CHIP-mediated hyperubiquitylation of tau promotes its self-assembly into the insoluble tau filaments
por: Kim, Ji Hyeon, et al.
Publicado: (2021)

Plasma Amyloid-β Oligomerization Tendency Predicts Amyloid PET Positivity
por: Pyun, Jung-Min, et al.
Publicado: (2021)

Change in cognitive function according to cholinesterase inhibitor use and amyloid PET positivity in patients with mild cognitive impairment
por: Pyun, Jung-Min, et al.
Publicado: (2021)

Coping with Dementia in the Middle of the COVID-19 Pandemic
por: Ryoo, Nayoung, et al.
Publicado: (2020)

Prediction of amyloid PET positivity via machine learning algorithms trained with EDTA-based blood amyloid-β oligomerization data
por: Youn, Young Chul, et al.
Publicado: (2022)

The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
por: Kawakami, Fumitaka, et al.
Publicado: (2015)

Predicting amyloid PET positivity using plasma p‐tau181 and other blood‐based biomarkers
por: Kwon, Hyuk Sung, et al.
Publicado: (2023)

Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease
por: Lee, Hyun‐ju, et al.
Publicado: (2021)

Impacts of baseline biomarkers on cognitive trajectories in subjective cognitive decline: the CoSCo prospective cohort study
por: Hong, Yun Jeong, et al.
Publicado: (2023)

Predictive Scale for Amyloid PET Positivity Based on Clinical and MRI Variables in Patients with Amnestic Mild Cognitive Impairment
por: Chun, Min Young, et al.
Publicado: (2022)

Differential White Matter Connectivity in Early Mild Cognitive Impairment According to CSF Biomarkers
por: Lim, Jae-Sung, et al.
Publicado: (2014)

Misplacement of something inside the refrigerator is not a sign of dementia, but a probable symptom of attention deficit due to depression
por: Suh, Jeewon, et al.
Publicado: (2021)

Interaction of CSF α‐synuclein and amyloid beta in cognition and cortical atrophy
por: Lee, Young‐gun, et al.
Publicado: (2021)

In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer’s brain
por: Nam, Won-Hee, et al.
Publicado: (2018)

Electroencephalography for Early Detection of Alzheimer’s Disease in Subjective Cognitive Decline
por: Shim, YongSoo, et al.
Publicado: (2022)

CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
por: Barthélemy, Nicolas R., et al.
Publicado: (2023)

Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease
por: Fossati, Silvia, et al.
Publicado: (2019)

Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro
por: Shin, Soo Jung, et al.
Publicado: (2020)

Study Design and Baseline Results in a Cohort Study to Identify Predictors for the Clinical Progression to Mild Cognitive Impairment or Dementia From Subjective Cognitive Decline (CoSCo) Study
por: Ho, SeongHee, et al.
Publicado: (2022)

Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease
por: Parnetti, Lucilla, et al.
Publicado: (2014)

Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations
por: Cap, Kim Cuong, et al.
Publicado: (2020)

Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimer’s disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial
por: Koh, Seong-Ho, et al.
Publicado: (2021)

Effects of GV1001 on Language Dysfunction in Patients With Moderate-to-Severe Alzheimer’s Disease: Post Hoc Analysis of Severe Impairment Battery Subscales
por: Kwon, Hyuk Sung, et al.
Publicado: (2023)

Extranodal NK/T-Cell Lymphoma Mimicking an Infectious Granuloma
por: Suh, Min Song, et al.
Publicado: (2019)

No added diagnostic value of non-phosphorylated tau fraction (p-tau(rel)) in CSF as a biomarker for differential dementia diagnosis
por: Goossens, Joery, et al.
Publicado: (2017)

Impact of an Education Program for Caregivers of Patients with Alzheimer's Disease on Treatment Discontinuation and Compliance in Korea
por: Kim, Hee-Jin, et al.
Publicado: (2021)

Alpha-synuclein and tau: teammates in neurodegeneration?
por: Moussaud, Simon, et al.
Publicado: (2014)

Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson’s Disease
por: Hu, Shanshan, et al.
Publicado: (2020)

Linked CSF reduction of phosphorylated tau and IL-8 in HIV associated neurocognitive disorder
por: Ozturk, Tugba, et al.
Publicado: (2019)

Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
por: Park, Jun Sung, et al.
Publicado: (2019)

Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation
por: Park, Jisu, et al.
Publicado: (2021)

Use of the Clock Drawing Test and the Rey–Osterrieth Complex Figure Test-copy with convolutional neural networks to predict cognitive impairment
por: Youn, Young Chul, et al.
Publicado: (2021)

Posterior atrophy predicts time to dementia in patients with amyloid-positive mild cognitive impairment
por: Pyun, Jung-Min, et al.
Publicado: (2017)

Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort
por: Shim, Yong S., et al.
Publicado: (2016)

Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism
por: Jung, Na-Yeon, et al.
Publicado: (2022)

Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling
por: Shin, Young‐Hee, et al.
Publicado: (2020)

Nanobiosensors for Non-Amyloidbeta-Tau Biomarkers as Advanced Reporters of Alzheimer’s Disease
por: Phan, Le Minh Tu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0c9j2ck1nj4pjuul7mmncc2c5c