Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages

Non-dividing cells of the myeloid lineage such as monocytes and macrophages are target cells of HIV that have low dNTP pool concentrations and elevated levels of dUTP, which leads to frequent incorporation of dUMP opposite to A during reverse transcription (“uracilation”). One factor determining the...

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Detalles Bibliográficos
Autores principales: Meshesha, Mesfin, Esadze, Alexandre, Cui, Junru, Churgulia, Natela, Sahu, Sushil Kumar, Stivers, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360050/
https://www.ncbi.nlm.nih.gov/pubmed/32663205
http://dx.doi.org/10.1371/journal.pone.0235012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360050/
https://www.ncbi.nlm.nih.gov/pubmed/32663205
http://dx.doi.org/10.1371/journal.pone.0235012

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