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Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages
Non-dividing cells of the myeloid lineage such as monocytes and macrophages are target cells of HIV that have low dNTP pool concentrations and elevated levels of dUTP, which leads to frequent incorporation of dUMP opposite to A during reverse transcription (“uracilation”). One factor determining the...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360050/ https://www.ncbi.nlm.nih.gov/pubmed/32663205 http://dx.doi.org/10.1371/journal.pone.0235012 |