Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

Affinity maturation is a complex dynamical process allowing the immune system to generate antibodies capable of recognizing antigens. We introduce a model for the evolution of the distribution of affinities across the antibody population in germinal centers. The model is amenable to detailed mathema...

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Detalles Bibliográficos
Autores principales: Molari, Marco, Eyer, Klaus, Baudry, Jean, Cocco, Simona, Monasson, Rémi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360369/
https://www.ncbi.nlm.nih.gov/pubmed/32538783
http://dx.doi.org/10.7554/eLife.55678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360369/
https://www.ncbi.nlm.nih.gov/pubmed/32538783
http://dx.doi.org/10.7554/eLife.55678

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