In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells

Microtubules (MTs) mediate mitosis, directional signaling, and are therapeutic targets in cancer. Yet in vivo analysis of cancer cell MT behavior within the tumor microenvironment remains challenging. Here we developed an imaging pipeline using plus-end tip tracking and intravital microscopy to quan...

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Detalles Bibliográficos
Autores principales: Luthria, Gaurav, Li, Ran, Wang, Stephanie, Prytyskach, Mark, Kohler, Rainer H., Lauffenburger, Douglas A., Mitchison, Timothy J., Weissleder, Ralph, Miller, Miles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360550/
https://www.ncbi.nlm.nih.gov/pubmed/32665556
http://dx.doi.org/10.1038/s41467-020-17147-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360550/
https://www.ncbi.nlm.nih.gov/pubmed/32665556
http://dx.doi.org/10.1038/s41467-020-17147-y

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