Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S

Enzymatic degradation of protein antigens by endo-lysosomal proteases in antigen-presenting cells is crucial for achieving cellular immunity. Structural changes caused by vaccine production process steps, such as formaldehyde inactivation, could affect the sensitivity of the antigen to lysosomal pro...

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Detalles Bibliográficos
Autores principales: Michiels, Thomas J. M., Meiring, Hugo D., Jiskoot, Wim, Kersten, Gideon F. A., Metz, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360561/
https://www.ncbi.nlm.nih.gov/pubmed/32665578
http://dx.doi.org/10.1038/s41598-020-68248-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360561/
https://www.ncbi.nlm.nih.gov/pubmed/32665578
http://dx.doi.org/10.1038/s41598-020-68248-z

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