High-throughput screening reveals higher synergistic effect of MEK inhibitor combinations in colon cancer spheroids

Drug combinations have been proposed to combat drug resistance, but putative treatments are challenged by low bench-to-bed translational efficiency. To explore the effect of cell culture format and readout methods on identification of synergistic drug combinations in vitro, we studied response to 21...

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Detalles Bibliográficos
Autores principales: Folkesson, Evelina, Niederdorfer, Barbara, Nakstad, Vu To, Thommesen, Liv, Klinkenberg, Geir, Lægreid, Astrid, Flobak, Åsmund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360566/
https://www.ncbi.nlm.nih.gov/pubmed/32665693
http://dx.doi.org/10.1038/s41598-020-68441-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360566/
https://www.ncbi.nlm.nih.gov/pubmed/32665693
http://dx.doi.org/10.1038/s41598-020-68441-0

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