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Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions

Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual disability, resulting from the presence of an extra complete or segment of chromosome 21 (HSA21). In addition, trisomy of HSA21 contributes to altered energy metabolism that appears to be a strong determinant in...

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Detalles Bibliográficos
Autores principales: Dierssen, Mara, Fructuoso, Marta, Martínez de Lagrán, María, Perluigi, Marzia, Barone, Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360727/
https://www.ncbi.nlm.nih.gov/pubmed/32733190
http://dx.doi.org/10.3389/fnins.2020.00670