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Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and use simulation studies to show that family-based analyses can reduce such biase...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360778/ https://www.ncbi.nlm.nih.gov/pubmed/32665587 http://dx.doi.org/10.1038/s41467-020-17117-4 |