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Mining and fine-tuning sugar uptake system for titer improvement of milbemycins in Streptomyces bingchenggensis
Dramatic decrease of sugar uptake is a general phenomenon in Streptomyces at stationary phase, when antibiotics are extensively produced. Milbemycins produced by Streptomyces bingchenggensis are a group of valuable macrolide biopesticides, while the low yield and titer impede their broad application...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
KeAi Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360889/ https://www.ncbi.nlm.nih.gov/pubmed/32695892 http://dx.doi.org/10.1016/j.synbio.2020.07.001 |