eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

RNA-activated protein kinase (PKR) is a major innate immune factor that senses viral double-stranded RNA (dsRNA) and phosphorylates eukaryotic initiation factor (eIF) 2α. Phosphorylation of the α subunit converts the eIF2αβγ complex into a stoichiometric inhibitor of eukaryotic initiation factor eIF...

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Detalles Bibliográficos
Autores principales: Wuerth, Jennifer Deborah, Habjan, Matthias, Kainulainen, Markus, Berisha, Besim, Bertheloot, Damien, Superti-Furga, Giulio, Pichlmair, Andreas, Weber, Friedemann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360930/
https://www.ncbi.nlm.nih.gov/pubmed/32665273
http://dx.doi.org/10.1128/mBio.00976-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360930/
https://www.ncbi.nlm.nih.gov/pubmed/32665273
http://dx.doi.org/10.1128/mBio.00976-20

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