Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1 by a cyclin-dependent kinase inhibitor. Overexpression of Mcl-1 ex...

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Detalles Bibliográficos
Autores principales: Felton, Jennifer M, Dorward, David A, Cartwright, Jennifer A, Potey, Philippe MD, Robb, Calum T, Gui, Jingang, Craig, Ruth W, Schwarze, Jürgen, Haslett, Christopher, Duffin, Rodger, Dransfield, Ian, Lucas, Christopher D, Rossi, Adriano G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361019/
https://www.ncbi.nlm.nih.gov/pubmed/32303624
http://dx.doi.org/10.1136/thoraxjnl-2019-213204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361019/
https://www.ncbi.nlm.nih.gov/pubmed/32303624
http://dx.doi.org/10.1136/thoraxjnl-2019-213204

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